ORDINANCES GOVERNING INTEGRATED M. Phil.-Ph.D. DEGREE in Life Sciences

1 · . The Courses of study leading to Integrated M. Phil.-Ph.D. Degree of the Banaras Hindu University shall be conducted at the DBT-BHU Interdisciplinary School of Life Sciences (ISLS) on full-time basis under the Institute of Science.

2 · . The Integrated M. Phil.-Ph.D. Degree Courses shall comprise of M. Phil. and Ph.D. components. The duration of the M. Phil. shall be one year (two semesters), whereas the duration of the Ph.D. shall be governed as per the provisions contained in the Ordinances governing the award of Doctor of Philosophy degree of the Banaras Hindu University. A student after successfully completing the M. Phil as per provisions contained in these Ordinances will have the option for exit with M. Phil. degree only or continue to the Ph.D. subject to fulfilling criteria described in clause IX.2 and IX.3 of this Ordinance.

3 · . The last date for receipt of applications for admission to this course shall be fixed each year by the University/Director, Institute of Science.

4 · . There shall be an Admission Committee for Integrated-M. Phil.-Ph.D. Courses, constituted under the provisions of Ordinances and consisting of the Director or his nominee and two senior members of the teaching staff. Admission shall be made in accordance with these ordinances and the rules made there under.

5 · . Provisional admissions to Integrated M. Phil-Ph.D. courses shall be based on combined merit comprising of Test score, Academic Record (calculated as per formula given in the Ph.D. Ordinances) and Interview. For admission into M. Phil-Ph.D. courses, the candidate shall have to appear at the RET as per Ph.D. ordinance of B.H.U. For NET/GATE qualified candidates, only interview will be held. 50% of seats will be filled with NET/GATE and 50% with RET qualified candidates. In case of vacancy, seats may be filled from either category.

6 · . All provisional admissions shall be finalized within the date notified by the University. Candidates are required to fulfill the minimum eligibility conditions on or before the date of counseling for admissions.

7 · . Provisional admissions cannot be claimed by any applicant as a matter of right. The provisional admission or readmission of an applicant shall be entirely at the discretion of the Admission Committee, which may refuse to admit any candidate without assigning any reason thereof.

8 · . Provisional admission shall be made strictly on the availability of seats on the date of admission and the mere fact that call letter has been issued shall not entitle a candidate to claim admission.

9 · . The candidate granted provisional admission shall deposit fee within the period prescribed by the Director, Institute of Science, failing which the admission shall stand cancelled.

10 · . Provisional admission of a candidate is liable to be cancelled by the Admission Committee at any time:

11 · . The candidates admitted to the respective Courses are required to submit the following certificates at the time of admission or by the time allowed by the Director, Institute of Science.

1 · . He/She must possess either of the following qualifying degrees:

2 · . He/She must have at least 50% in the aggregate or equivalent grade point average in the examination of the qualifying degree.

4 · . The vacant seats reserved for SC/ST/OBC candidates, if any, shall be filled as per GOI Rules.

5 · . 3% seats, on horizontal reservation basis, shall be reserved for PC (Physically Challenged) candidates (visually impaired 1% + hearing impaired 1% + orthopedically handicapped 1%), provided they fulfill the minimum eligibility requirements (for PC candidates a relaxation of 5% marks in aggregate in qualifying examination is provided in comparison to the requirement of minimum eligibility prescribed for general candidates) and qualify in the Test Examination. They shall have to submit a PC certificate issued by the district CMO at the time of submitting the application. Candidates who claim for PC category shall be considered under this category on an approval from the University Medical Board only at the time of admission.

4 · . Test will be conducted once a year before the July/September term.

10 · questions for testing logical thinking

10 · questions for testing quantitative ability

10 · questions for testing general knowledge

10 · questions for testing awareness of computer usages

20 · questions for testing language skills (this Test will include three subsets of 10 questions each relating to knowledge of Hindi, English and Sanskrit, respectively, of which the candidate may answer any two subsets (10+10 questions in any two languages)

5 · . Names of as many candidates as the number of vacancies given in the Information Bulletin will be announced on the basis of Final Merit Order after Test C for a dmission . An equal number of wait-listed candidates (in order of merit) will also be prepared for consideration in case seats remain vacant .

6 · . Non -appearance of the candidate in RET , Test C and Interview on the scheduled date an d time shall disqualify him/her for admission .

7 · . Mere appearance in the RET and Interview shall not entitle a candidate to be considered for admission to the courses unless he/she fulfils the eligibility conditions . Applicants must fully satisfy themselves about their eligibility before filling the application forms of RET .

11 · . A candidate provisionally selected for admission shall be required to fill the prescribed form , submit the required documents , collect his/her admit card for a dmission to the course from the office of the Department and pay fees by a date fixed for the purpose , otherwise the offer made to him/her will automatically stand cancelled .

12 · . In case any provisionally selected candidate fails to deposit the fee by the last date

13 · . Wait-listed candidate shall be offered admissions strictly on the basis of ranking provided there is a vacancy in the Courses . Such waitlisted candidates shall have to deposit their fee latest by the date fixed by the Admission Committee .

2 · . The attendance of a newly admitted candidate shall be counted from the date of his/her admission , or date of beginning of classes whichever is later , w hile in the case of promoted candidates , attendance shall be counted from the date on which respective class begins . However in case of promotion after declaration of results of supplementary examination (if any) , the attendance will be counted from the date of admission in the respective case .

2 · . End Semester Examination and evaluation (for 70 % marks):

3 · . Admit Card (for End Semester Examinations):

1 · M . Phil . (Two Semesters) Course

2 · . Option for Exit with M. Phil. Degree only or Continuation for Ph.D. course

3 · . Migration of pass-outs of M.Phil. Degree to the Ph.D. course of the Integrated M.Phil.-Ph.D. in Life Sciences

4 · . Ordinance applicable during Ph . D . Course

2 · 1 Nucleic Acids: DNA- Watson-Crick double helix model, tools for studying DNA structure, Central dogma and epigenetic modifications, RNA- coding and non-coding, relevance of noncoding RNA in gene expression regulation

2 · 2 Carbohydrates: types- simple and complex, relevance in energy metabolism

2 · 3 Proteins: sorting, trafficking, post translational modifications

2 · 4 Lipids: types- lipoprotein complex and role in lipid transport.

3 · . Cell Cycle

3 · 1. Overview of the cell cycle

3 · 2. Cell cycle regulation

4 · 1. Concept of ligand, receptor and second messenger

4 · 2. Signaling through G-Protein-Coupled Receptors (GPCRs)

4 · 3. Signaling through enzyme-coupled cell surface receptors: RTK, PI-3-kinase/AKT, JAK/STAT, TGF-beta/Smad, NF-kB

4 · 4. Signaling pathways involved in development: Notch, Wingless, Hedgehog

4 · 5. Nuclear receptor superfamily

4 · 6. Signaling crosstalk

5 · 1 Concept of free energy, determination of ∆G, ∆G and oxidation-reduction reactions

5 · 2 Energy rich compounds- ATP, Acyl phosphates, thiol esters, guanidinium phosphates

5 · 3 Energy production- substrate level and oxidative phosphorylation, mitochondrial

5 · 4 Photosynthesis-Light harvesting complexes, mechanism of electron transport, photoprotective mechanism, non-photochemical quenching and state transition.

6 · 1 Competence, induction, specification and differentiation

6 · 2 Early development in Sea Urchin, frog and chick model systems

6 · 3 Body Pattern formation in Drosophila embryo, Vertebrate limb patterning

6 · 4 Morphogenesis in cyanobacteria using model organism, Fremyella diplosiphon

6 · 5 Cell differentiation, root and shoot development, and floral development in Arabidopsis

7 · . Cell transformation and tumorigenesis

7 · 1 Evolution of cancer

7 · 2 Oncogenes and Tumour suppressor genes

7 · 3 Genomic instability

8 · 1 Responses of plant to biotic and abiotic stresses

8 · 2 Molecular mechanisms of signal transduction during stress

1 · 1. Acrosomal reaction and gamete interaction

1 · 2. Prevention of polyspermy

2 · 1. Cleavage

2 · 2. Gastrulation (amphibians and aves)

2 · 3. General concept of potency, commitment, specification, induction and competence

3 · 1. Stalk and fruiting body formation in Dictyostelium

3 · 2. Anterior-posterior and dorso-ventral polarity and pattern formation in Drosophila, HOX genes and patterning in frog, chick and mammals

4 · 1 Vulva formation in Caenorhabditis

4 · 2 Neural tube development and limb patterning in vertebrates

7 · 1. Congenital malformation and teretogenesis

7 · 2. Reproductive failure and assisted reproduction

1 · 1 Chromatin organization

1 · 2 DNA replication

1 · 3 Transcription

1 · 4 Promoter analysis and characterization

1 · 5 Post transcriptional gene silencing

1 · 6 Epigenetic regulation of gene expression

2 · 1 Structures, determination of primary structure, structure-function relations

2 · 2 Translation and regulation

2 · 3 Interferons and their applications

3 · Enzymology

3 · 1 Applications of enzyme kinetics

3 · 2 Enzyme: distribution, diversity and evolution

3 · 3 Principles and applications of enzyme assay

3 · 4 Enzyme technology- markers, sensors, diagnosis

4 · 1 Concept of metabolic energy transduction

4 · 2 Regulatory mechanisms of major metabolic pathways and their significance

5 · 1 Glycogen storage disease

5 · 2 Mucopolyscharidosis

5 · 3 Diabetes mellitus

1 · 1 Nitrogenase enzyme

1 · 2 Substrates for nitrogenase

1 · 3 Mechanism of reaction and its regulation

2 · 1 Nitrate and nitrite reductases, their inhibitors

2 · 2 Localization and regulation

2 · 3 Pathways of ammonia assimilation

2 · 4 Regulation of nitrogen assimilation

3 · 1 Sulphate uptake, activation and transfer

3 · 2 Assimilatory pathways of sulphate reduction

3 · 3 Transport and assimilation of phosphate

4 · 1 Gene transfer methods: particle bombardment, electroporation, PEG and Agrobacterium mediated; floral dip method

4 · 2 Marker and reporter genes

4 · 3 Marker-free transgenic

4 · 4 Transgene silencing

5 · 1 Concept mapping and sequencing of genomes: Arabidopsis, rice and tomato

5 · 2 Genome annotation

5 · 3 Approaches to analyze differential expression of genes

5 · 4 Principles of reverse genetics

5 · 5 Gene tagging, Gene trapping and Gene silencing

5 · 6 Genome engineering/editing technologies (ZFNs, TALENs, CRISPR/Cas9, Recombineering)

1 · 1 Brain structure: regional organization, neural system, circuit

1 · 2 Neurons and glia

1 · 3 Blood brain barrier

2 · 1 Membrane potential, action potential, transmission of nerve impulse

2 · 3 Synapse: types, synaptic transmission- chemical and electrical

2 · 4 Excitatory and inhibitory post-synaptic potential

2 · 5 Chemical transmission, neurotransmitters (acetylcholine, catecholamines, serotonin and GABA), neuropeptides

3 · 1 Types

3 · 2 Synaptic plasticity, Hebb’s Rule

3 · 3 Tools for memory assessment- Morris water maze, Radial arm maze

3 · 4 Molecular mechanisms

4 · 1 Motivation

4 · 2 Sleep- types, mechanisms

5 · 1 CAT

5 · 2 PET

5 · 3 MRI

7 · 1 Strokes

7 · 2 Epilepsy

7 · 3 Alzheimer disease

7 · 4 Huntington disease

7 · 5 Parkinson disease

3 · 1 Gene frequency in Mendelian population

3 · 2 Hardy-Weinberg equilibrium

3 · 3 Conditions for the maintenance of genetic equilibrium

4 · 1 Mutation

4 · 2 Natural selection

4 · 3 Random genetic drift

4 · 4 Migration

9 · 1 Molecular phylogenies

9 · 2 Neutral theory

9 · 3 Molecular clock